Inhibition of phagocytosis of human macrophages induced by airborne particulates.
Toxicol Lett
; 72(1-3): 23-31, 1994 Jun.
Article
in En
| MEDLINE
| ID: mdl-8202937
ABSTRACT
Human monocyte-derived macrophages isolated from peripheral blood were treated with different extracts of airborne particulates collected in the highly industrialized Rhine-Ruhr area. All tested extracts showed a substantial impairment of phagocytosis by inhibition of phagocytic activity as well as phagocytic capacity, while cell viability was rather well maintained. Significant reduction of phagocytosis already appeared at a concentration equivalent to extracted particulates from 3.8 m3 air. Having properties of alveolar macrophages, human monocyte-derived macrophage cultures may offer a reliable in vitro model for assessment of pulmonary toxicity by respirable pollutants.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phagocytosis
/
Macrophages, Alveolar
/
Air Pollutants
Limits:
Humans
Language:
En
Journal:
Toxicol Lett
Year:
1994
Document type:
Article
Affiliation country:
Germany