Administration of recombinant human IL-7 to mice alters the composition of B-lineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases.

Komschlies, K L; Gregorio, T A; Gruys, M E; Back, T C; Faltynek, C R; Wiltrout, R H

Komschlies, K L; Gregorio, T A; Gruys, M E; Back, T C; Faltynek, C R; Wiltrout, R H.

Affiliation

Komschlies KL; Biological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, Frederick, MD 21702.

J Immunol ; 152(12): 5776-84, 1994 Jun 15.

Article in En | MEDLINE | ID: mdl-8207207

Subject(s)

B-Lymphocytes/immunology; Interleukin-7/pharmacology; Neoplasm Metastasis/immunology; T-Lymphocyte Subsets/immunology; Animals; Antigens, Differentiation/metabolism; Carcinoma, Renal Cell/immunology; Carcinoma, Renal Cell/secondary; Carcinoma, Renal Cell/therapy; Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Humans; Interleukin-7/administration & dosage; Kidney Neoplasms/immunology; Kidney Neoplasms/secondary; Kidney Neoplasms/therapy; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Recombinant Proteins/administration & dosage; Recombinant Proteins/pharmacology; Spleen/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / T-Lymphocyte Subsets / Interleukin-7 / Neoplasm Metastasis Limits: Animals / Humans Language: En Journal: J Immunol Year: 1994 Document type: Article

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