A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies.

Wonacott, A; Cooke, R; Hayes, F R; Hann, M M; Jhoti, H; McMeekin, P; Mistry, A; Murray-Rust, P; Singh, O M; Weir, M P

Wonacott, A; Cooke, R; Hayes, F R; Hann, M M; Jhoti, H; McMeekin, P; Mistry, A; Murray-Rust, P; Singh, O M; Weir, M P.

Affiliation

Wonacott A; Protein Structure Group, Glaxo Group Research Limited, Greenford, Middlesex, United Kingdom.

J Med Chem ; 36(21): 3113-9, 1993 Oct 15.

Article in En | MEDLINE | ID: mdl-8230097

Subject(s)

HIV Protease Inhibitors/chemical synthesis; HIV Protease Inhibitors/pharmacology; Penicillins/chemical synthesis; Penicillins/pharmacology; Amino Acid Sequence; Binding Sites; Crystallography; HIV Protease/chemistry; HIV Protease Inhibitors/chemistry; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Penicillins/chemistry; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Penicillins / HIV Protease Inhibitors Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1993 Document type: Article Affiliation country: United kingdom Country of publication: United States

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