Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors containing a stereochemically unique peptide isostere.

Holmes, D S; Bethell, R C; Cammack, N; Clemens, I R; Kitchin, J; McMeekin, P; Mo, C L; Orr, D C; Patel, B; Paternoster, I L

Holmes, D S; Bethell, R C; Cammack, N; Clemens, I R; Kitchin, J; McMeekin, P; Mo, C L; Orr, D C; Patel, B; Paternoster, I L.

Affiliation

Holmes DS; Department of Medicinal Chemistry II, Glaxo Group Research Limited, Greenford, Middlesex, United Kingdom.

J Med Chem ; 36(21): 3129-36, 1993 Oct 15.

Article in En | MEDLINE | ID: mdl-8230099

Subject(s)

Antiviral Agents/chemical synthesis; HIV Protease Inhibitors/chemical synthesis; Penicillins/chemical synthesis; Thiazoles/chemical synthesis; Amino Acid Sequence; Antiviral Agents/chemistry; Antiviral Agents/pharmacology; Binding Sites; HIV Protease Inhibitors/chemistry; HIV Protease Inhibitors/pharmacology; Models, Molecular; Molecular Sequence Data; Penicillins/chemistry; Penicillins/pharmacology; Stereoisomerism; Structure-Activity Relationship; Thiazoles/chemistry; Thiazoles/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Penicillins / Thiazoles / HIV Protease Inhibitors Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1993 Document type: Article Affiliation country: United kingdom Country of publication: United States

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