Epstein-Barr virus and primary lung lymphoma: a study utilizing the polymerase chain reaction.
Mod Pathol
; 6(5): 575-80, 1993 Sep.
Article
in En
| MEDLINE
| ID: mdl-8248115
ABSTRACT
Seven cases of primary lung lymphoma were analyzed for the presence of Epstein-Barr virus DNA sequences by the polymerase chain reaction. The series included four cases of diffuse, small lymphocytic lymphoma; one case of diffuse, intermediate lymphocytic lymphoma; one case of diffuse, small cleaved cell lymphoma; and one case of large cell, immunoblastic lymphoma. The latter occurred in a patient with acquired immunodeficiency syndrome. A 200-bp sequence of the Epstein-Barr nuclear antigen 1 gene was used as a template for PCR amplification. The only tumor that contained Epstein-Barr virus sequences was the immunoblastic lymphoma. These findings support previous observations that small lymphocytic lymphomas of the lung are not related to Epstein-Barr virus infection. In contrast, some large cell lymphomas may represent Epstein-Barr-virus--associated lymphoproliferative disorders.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA, Viral
/
Polymerase Chain Reaction
/
Herpesvirus 4, Human
/
Lung Neoplasms
/
Lymphoma
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Mod Pathol
Journal subject:
PATOLOGIA
Year:
1993
Document type:
Article