A novel factor Xa inhibitor: structure-activity relationships and selectivity between factor Xa and thrombin.

Katakura, S; Nagahara, T; Hara, T; Iwamoto, M

Katakura, S; Nagahara, T; Hara, T; Iwamoto, M.

Affiliation

Katakura S; Exploratory Research Laboratories 2, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.

Biochem Biophys Res Commun ; 197(2): 965-72, 1993 Dec 15.

Article in En | MEDLINE | ID: mdl-8267636

Subject(s)

Amidines/pharmacology; Factor Xa Inhibitors; Factor Xa/chemistry; Propionates/pharmacology; Protease Inhibitors/pharmacology; Pyrrolidines/pharmacology; Thrombin/antagonists & inhibitors; Thrombin/chemistry; Amidines/chemical synthesis; Amidines/chemistry; Amino Acid Sequence; Animals; Cattle; Crystallography, X-Ray; Glutamine; Humans; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Propionates/chemistry; Protein Conformation; Pyrrolidines/chemistry; Sequence Homology, Amino Acid; Structure-Activity Relationship; Trypsin/chemistry

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Protease Inhibitors / Pyrrolidines / Thrombin / Factor Xa / Factor Xa Inhibitors / Amidines Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 1993 Document type: Article Affiliation country: Japan Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links