Effects of fludrocortisone on sympathetic nerve activity in humans.
Hypertension
; 23(1): 123-30, 1994 Jan.
Article
in En
| MEDLINE
| ID: mdl-8282323
ABSTRACT
Fludrocortisone reduces plasma norepinephrine in healthy humans, but forearm vascular and pressor responses to norepinephrine are potentiated. The effects of fludrocortisone on sympathetic nerve activity in healthy humans are not known. To investigate these effects we evaluated muscle sympathetic nerve activity, heart rate, and arterial pressure in 11 healthy volunteers during three protocols (1) before and on day 7 of fludrocortisone (0.4 mg/d) treatment with ad libitum diet (n = 6); (2) before and on day 7 of fludrocortisone (0.4 mg/d) or placebo with a 150 mmol/24 h (mEq/24 h) sodium diet (n = 7); and (3) before and on day 2 of fludrocortisone (0.4 mg/d) or placebo with a 150 mmol/24 h (mEq/24 h) sodium diet (n = 4). Placebo did not alter any parameter.(ABSTRACT TRUNCATED AT 250 WORDS)
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sympathetic Nervous System
/
Fludrocortisone
Type of study:
Clinical_trials
/
Guideline
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Hypertension
Year:
1994
Document type:
Article