The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury. Reversal by tirilazad mesylate (U-74006F).

Althaus, J S; Andrus, P K; Williams, C M; VonVoigtlander, P F; Cazers, A R; Hall, E D

Althaus, J S; Andrus, P K; Williams, C M; VonVoigtlander, P F; Cazers, A R; Hall, E D.

Affiliation

Althaus JS; CNS Diseases Research, Upjohn Company, Kalamazoo, MI 49001.

Mol Chem Neuropathol ; 20(2): 147-62, 1993 Oct.

Article in En | MEDLINE | ID: mdl-8297419

Subject(s)

Brain Injuries/metabolism; Brain Ischemia/metabolism; Gentisates; Hydroxyl Radical/metabolism; Lipid Peroxides/antagonists & inhibitors; Pregnatrienes/pharmacology; Salicylates/metabolism; Animals; Free Radical Scavengers; Hydroxybenzoates/metabolism; Hydroxylation; Male; Mice; Salicylic Acid

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Collection: 01-internacional Database: MEDLINE Main subject: Pregnatrienes / Brain Injuries / Brain Ischemia / Salicylates / Hydroxyl Radical / Gentisates / Lipid Peroxides Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Chem Neuropathol Journal subject: BIOLOGIA MOLECULAR / NEUROLOGIA / PATOLOGIA / QUIMICA Year: 1993 Document type: Article Country of publication: United States

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