Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).

Pavlovic, M; Leffert, J J; Russello, O; Bunni, M A; Beardsley, G P; Priest, D G; Pizzorno, G

Pavlovic, M; Leffert, J J; Russello, O; Bunni, M A; Beardsley, G P; Priest, D G; Pizzorno, G.

Affiliation

Pavlovic M; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.

Adv Exp Med Biol ; 338: 775-8, 1993.

Article in En | MEDLINE | ID: mdl-8304227

Subject(s)

Carrier Proteins/metabolism; Folic Acid Antagonists/metabolism; Folic Acid/metabolism; Receptors, Cell Surface/metabolism; Tetrahydrofolates/toxicity; Binding Sites; Biological Transport; Cell Line; Drug Resistance; Folate Receptors, GPI-Anchored; Humans; Kinetics; Methotrexate/metabolism; Peptide Synthases/metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Tetrahydrofolates/metabolism; Tumor Cells, Cultured

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Tetrahydrofolates / Receptors, Cell Surface / Folic Acid / Folic Acid Antagonists Limits: Humans Language: En Journal: Adv Exp Med Biol Year: 1993 Document type: Article Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links