Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.

James, G L; Goldstein, J L; Brown, M S; Rawson, T E; Somers, T C; McDowell, R S; Crowley, C W; Lucas, B K; Levinson, A D; Marsters, J C

James, G L; Goldstein, J L; Brown, M S; Rawson, T E; Somers, T C; McDowell, R S; Crowley, C W; Lucas, B K; Levinson, A D; Marsters, J C.

Affiliation

James GL; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.

Science ; 260(5116): 1937-42, 1993 Jun 25.

Article in En | MEDLINE | ID: mdl-8316834

Subject(s)

Alkyl and Aryl Transferases; Antineoplastic Agents/pharmacology; Benzodiazepinones/pharmacology; Oncogene Proteins/metabolism; Protein Prenylation/drug effects; Transferases/antagonists & inhibitors; Amino Acid Sequence; Animals; Antineoplastic Agents/chemistry; Benzodiazepinones/chemistry; CHO Cells; Cell Division/drug effects; Cell Line, Transformed; Cell Transformation, Neoplastic/drug effects; Cricetinae; Drug Design; Farnesyltranstransferase; Molecular Sequence Data; Oligopeptides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Transferases / Benzodiazepinones / Protein Prenylation / Oncogene Proteins / Alkyl and Aryl Transferases / Antineoplastic Agents Limits: Animals Language: En Journal: Science Year: 1993 Document type: Article Country of publication: United States

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