Gastrin and gastrin-related responses to infection with Ostertagia ostertagi in the calf.
Res Vet Sci
; 54(3): 384-91, 1993 May.
Article
in En
| MEDLINE
| ID: mdl-8337488
ABSTRACT
The effects of a single challenge with 60,000 infective Ostertagia ostertagi larvae on blood and gastrointestinal mucosal gastrin concentrations, gastrin-producing G-cell numbers in the pyloric mucosa and growth of different parts of the gut were investigated in 16, two-and-a-half-month-old calves. Infected calves exhibited a rise in abomasal pH which was accompanied by a 145 per cent increase in wet weight of the fundic mucosa (P < 0.05) and a significant rise in blood total gastrin concentrations (P < 0.01). Circulating little gastrin (G-17) was unaffected. Pyloric mucosal total gastrin concentrations remained unaltered in the infected calves until day 28 when levels fell to 36.9 per cent of control group values (P < 0.01). Pyloric mucosal G-cell numbers declined during the experiment in the infected group. It is suggested that release of previously stored tissue gastrin and not a change in G-cell numbers contributes to the hypergastrinaemia associated with ostertagia infection in the calf.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ostertagiasis
/
Gastrins
/
Cattle Diseases
/
Gastric Mucosa
Limits:
Animals
Language:
En
Journal:
Res Vet Sci
Year:
1993
Document type:
Article