Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.

de Costa, B R; He, X S; Linders, J T; Dominguez, C; Gu, Z Q; Williams, W; Bowen, W D

de Costa, B R; He, X S; Linders, J T; Dominguez, C; Gu, Z Q; Williams, W; Bowen, W D.

Affiliation

de Costa BR; Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.

J Med Chem ; 36(16): 2311-20, 1993 Aug 06.

Article in En | MEDLINE | ID: mdl-8360875

Subject(s)

Ethylamines/chemical synthesis; Receptors, sigma/metabolism; Animals; Brain/metabolism; Ethylamines/chemistry; Ethylamines/metabolism; Guinea Pigs; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, sigma / Ethylamines Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1993 Document type: Article

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