Estrogen potentiating activity of two spiro compounds having approximately similar molecular dimensions to stilbestrol.
J Med Chem
; 20(2): 318-20, 1977 Feb.
Article
in En
| MEDLINE
| ID: mdl-836507
ABSTRACT
Pharmacological investigation of members of a series of synthetic spiro derivatives with similar molecular dimensions to stilbestrol revealed that two compounds, spiro[cyclohexane-1,2'-tetralin]-1,4'-dione and spiro[cyclohexane-1,2'-indan]-1,4'-diol, exhibited a marked ability to potentiate stilbestrol at doses which had no intrinsic estrogenic activity. It is postulated that such compounds may be of use in reducing the side effects associated with estrogen therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spiro Compounds
/
Diethylstilbestrol
Limits:
Animals
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
1977
Document type:
Article