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11q- and constitutional X trisomy in a patient with M5b acute non-lymphocytic leukemia.
Bigazzi, C; Galieni, P; Scarinci, R; Vivarelli, R; Bucalossi, A; Biancolini, G; Falbo, R; Vessichelli, F; Dispensa, E.
Affiliation
  • Bigazzi C; Cattedra e Divisione di Ematologia, Siena, Italy.
Haematologica ; 78(3): 185-6, 1993.
Article in En | MEDLINE | ID: mdl-8375750
ABSTRACT
A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subsequently, two courses of chemotherapy for resistant ANLL were administered without achieving complete remission. Abnormalities of chromosome 11 are typical of M4 and M5 ANLL. X trisomy is one of the most common human aneuploidia; however, correlation with increased incidence of hematological neoplasia has not been described.
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Collection: 01-internacional Database: MEDLINE Main subject: Trisomy / X Chromosome / Chromosomes, Human, Pair 11 / Leukemia, Myeloid, Acute Limits: Female / Humans / Middle aged Language: En Journal: Haematologica Year: 1993 Document type: Article Affiliation country: Italy
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Trisomy / X Chromosome / Chromosomes, Human, Pair 11 / Leukemia, Myeloid, Acute Limits: Female / Humans / Middle aged Language: En Journal: Haematologica Year: 1993 Document type: Article Affiliation country: Italy