'W' mutant forms of the Fms receptor tyrosine kinase act in a dominant manner to suppress CSF-1 dependent cellular transformation.

Reith, A D; Ellis, C; Maroc, N; Pawson, T; Bernstein, A; Dubreuil, P

Reith, A D; Ellis, C; Maroc, N; Pawson, T; Bernstein, A; Dubreuil, P.

Affiliation

Reith AD; Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

Oncogene ; 8(1): 45-53, 1993 Jan.

Article in En | MEDLINE | ID: mdl-8380922

Subject(s)

Cell Transformation, Neoplastic; Macrophage Colony-Stimulating Factor/pharmacology; Protein-Tyrosine Kinases/physiology; Receptor, Macrophage Colony-Stimulating Factor/physiology; Receptors, Cell Surface/physiology; Animals; Cells, Cultured; Point Mutation; Rats; Receptor, Macrophage Colony-Stimulating Factor/drug effects; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Cell Transformation, Neoplastic / Macrophage Colony-Stimulating Factor / Receptor, Macrophage Colony-Stimulating Factor / Receptors, Cell Surface Limits: Animals Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 1993 Document type: Article Affiliation country: Canada

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