Effect of N-methyl substitution of the peptide bonds in luteinizing hormone-releasing hormone agonists.

Haviv, F; Fitzpatrick, T D; Swenson, R E; Nichols, C J; Mort, N A; Bush, E N; Diaz, G; Bammert, G; Nguyen, A; Rhutasel, N S

Haviv, F; Fitzpatrick, T D; Swenson, R E; Nichols, C J; Mort, N A; Bush, E N; Diaz, G; Bammert, G; Nguyen, A; Rhutasel, N S.

Affiliation

Haviv F; Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064.

J Med Chem ; 36(3): 363-9, 1993 Feb 05.

Article in En | MEDLINE | ID: mdl-8381183

Subject(s)

Gonadotropin-Releasing Hormone/analogs & derivatives; Amino Acid Sequence; Animals; Chymotrypsin/metabolism; Gonadotropin-Releasing Hormone/chemical synthesis; Gonadotropin-Releasing Hormone/metabolism; Gonadotropin-Releasing Hormone/pharmacology; In Vitro Techniques; Intestinal Mucosa/metabolism; Leuprolide/analogs & derivatives; Leuprolide/pharmacology; Luteinizing Hormone/metabolism; Male; Methylation; Models, Molecular; Molecular Sequence Data; Nafarelin/analogs & derivatives; Nafarelin/pharmacology; Peptides/chemical synthesis; Peptides/pharmacology; Pituitary Gland/metabolism; Rats; Receptors, LHRH/metabolism; Structure-Activity Relationship; Triptorelin Pamoate/analogs & derivatives

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Collection: 01-internacional Database: MEDLINE Main subject: Gonadotropin-Releasing Hormone Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1993 Document type: Article Country of publication: United States

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