Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.
Brain Res
; 600(2): 235-42, 1993 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-8382098
The role of GABAb receptor activation in the expression of both interictal and ictal phenomena was investigated in slices of area CA3 of the rat hippocampal formation. Interictal-like bursts occurred following application of high frequency trains to the Schaffer collaterals. When two bursts were triggered using paired stimuli, profound depression of the second burst was seen 150-600 ms following the first burst. GABAb receptor antagonists potently reversed the paired pulse depression of the interictal-like bursts. Reversal of the paired depression was also accomplished by increasing the extracellular concentration of K+ by 2-3 mM. Additional experiments were performed in area CA3 to determine the role of GABAb receptor activation on the expression of ictal phenomena. Electrographic seizures (EGSs) were induced by application of high frequency trains. 2-Hydroxy-saclofen (200 microM) significantly decreased the duration of trains required to elicit EGSs. Taken together, these data suggest that GABAb receptor activation has potent inhibitory effects on both ictal and interictal-like events.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, GABA-A
/
Hippocampus
/
Anticonvulsants
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
1993
Document type:
Article
Country of publication:
Netherlands