In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle.

Mosseri, M; Fingert, H J; Varticovski, L; Chokshi, S; Isner, J M

Mosseri, M; Fingert, H J; Varticovski, L; Chokshi, S; Isner, J M.

Affiliation

Mosseri M; Department of Medicine, St. Elizabeth's Hospital, Tufts University School of Medicine, Boston, Massachusetts 02135.

Cancer Res ; 53(13): 3028-33, 1993 Jul 01.

Article in En | MEDLINE | ID: mdl-8391384

Subject(s)

Fluorouracil/toxicity; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/enzymology; Myocardial Ischemia/chemically induced; Myocardial Ischemia/enzymology; Protein Kinase C/physiology; Vasoconstriction/physiology; Animals; Antineoplastic Agents/toxicity; Calcium Channels/drug effects; Calcium Channels/physiology; Drug Interactions; Endothelium, Vascular/drug effects; Endothelium, Vascular/enzymology; Endothelium, Vascular/metabolism; Fluorouracil/antagonists & inhibitors; In Vitro Techniques; Male; Muscle, Smooth, Vascular/metabolism; Myocardial Ischemia/physiopathology; Nitroglycerin/pharmacology; Phosphatidylinositols/metabolism; Prostaglandin-Endoperoxide Synthases/metabolism; Protein Kinase C/metabolism; Rabbits; Receptors, Adrenergic/drug effects; Receptors, Adrenergic/physiology; Structure-Activity Relationship; Time Factors; Vasoconstriction/drug effects; Vasoconstrictor Agents/antagonists & inhibitors; Vasoconstrictor Agents/toxicity

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Collection: 01-internacional Database: MEDLINE Main subject: Vasoconstriction / Protein Kinase C / Myocardial Ischemia / Fluorouracil / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: Cancer Res Year: 1993 Document type: Article Country of publication: United States

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