A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines.

Naylor, A; Judd, D B; Lloyd, J E; Scopes, D I; Hayes, A G; Birch, P J

Naylor, A; Judd, D B; Lloyd, J E; Scopes, D I; Hayes, A G; Birch, P J.

Affiliation

Naylor A; Department of Medicinal Chemistry, Glaxo Group Research Ltd., Ware, Hertfordshire, England.

J Med Chem ; 36(15): 2075-83, 1993 Jul 23.

Article in En | MEDLINE | ID: mdl-8393489

Subject(s)

Analgesics/chemical synthesis; Piperazines/chemical synthesis; Pyrrolidines/chemical synthesis; Receptors, Opioid, kappa/drug effects; Analgesics/pharmacology; Animals; Cricetinae; Male; Mice; Molecular Conformation; Piperazines/pharmacology; Pyrrolidines/pharmacology; Rabbits; Rats; Stereoisomerism; Structure-Activity Relationship; Vas Deferens/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrrolidines / Receptors, Opioid, kappa / Analgesics Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1993 Document type: Article Affiliation country: United kingdom

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