Your browser doesn't support javascript.
loading
Guanosine potentiates the antiproliferative effect of cytosine-beta-D-arabinofuranoside in melanoma cell lines.
Sidi, Y; Panet, C; Cyjon, A; Fenig, E; Beery, E; Nordenberg, J.
Affiliation
  • Sidi Y; Basil and Gerald Felsenstein Medical Research Center, Department of Medicine D, Beilinson Medical Center, Petah-Tikva, Israel.
Cancer Invest ; 11(5): 523-9, 1993.
Article in En | MEDLINE | ID: mdl-8402221
Guanosine is shown to potentiate markedly the antiproliferative effect of cytosine-beta-D-arabinoside (ara-C) on B16 F10 mouse and SKMEL-28 human melanoma cell lines. Several metabolic consequences of the synergistic interaction between ara-C and guanosine on cell growth were determined in B16 F10 mouse melanoma cells. Treatment of the cells with guanosine for 24 hr resulted in an increase in the percentage of cells in the S phase of the cell cycle, a threefold increase in intracellular GTP concentration, and an increase in the incorporation of ara-C into acid-insoluble material and phosphorylated metabolites. These findings suggest that guanosine potentiates the growth-inhibitory effect of ara-C in B16 F10 melanoma cells by increasing the intracellular concentration of its active metabolites.
Subject(s)
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Cytarabine / Guanosine / Melanoma Limits: Animals / Humans Language: En Journal: Cancer Invest Year: 1993 Document type: Article Affiliation country: Israel Country of publication: United kingdom
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Cytarabine / Guanosine / Melanoma Limits: Animals / Humans Language: En Journal: Cancer Invest Year: 1993 Document type: Article Affiliation country: Israel Country of publication: United kingdom