Brainstem auditory evoked potential interwave intervals are prolonged in vitamin B-6-deficient cats.
J Nutr
; 123(1): 20-6, 1993 Jan.
Article
in En
| MEDLINE
| ID: mdl-8421226
ABSTRACT
Vitamin B-6 deficiency has been reported to produce behavioral, neurophysiological and neuropathological abnormalities in a variety of species. In this investigation we used brainstem auditory evoked potentials (BAEP) to determine if vitamin B-6 deficiency in cats affected peripheral and brainstem auditory pathways. Brainstem auditory evoked potentials were recorded from growing cats as they developed vitamin B-6 deficiency, which was confirmed using clinical, hematological and urinary criteria. The BAEP interwave intervals measured from early (wave 1 or 1N) to late waves (5N) or from middle (wave 3) to late waves increased significantly, whereas interwave intervals from early to middle waves did not differ significantly. These results indicate that vitamin B-6 deficiency affects one or more structures of the brainstem that generate the later parts of the BAEP. The finding of prolonged interwave intervals in vitamin B-6-deficient animals is consistent with slowed axonal conduction velocity secondary to defective myelination. Recording BAEP provided a noninvasive means of detecting effects of vitamin B-6 deficiency on specific parts of the central nervous system.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin B 6 Deficiency
/
Evoked Potentials, Auditory, Brain Stem
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Nutr
Year:
1993
Document type:
Article