Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.

Scarborough, P E; Guruprasad, K; Topham, C; Richo, G R; Conner, G E; Blundell, T L; Dunn, B M

Scarborough, P E; Guruprasad, K; Topham, C; Richo, G R; Conner, G E; Blundell, T L; Dunn, B M.

Affiliation

Scarborough PE; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville 32610.

Protein Sci ; 2(2): 264-76, 1993 Feb.

Article in En | MEDLINE | ID: mdl-8443603

Subject(s)

Cathepsin D/metabolism; Chromogenic Compounds/metabolism; Oligopeptides/metabolism; Amino Acid Sequence; Aspartic Acid Endopeptidases/metabolism; Cathepsin D/chemistry; Cathepsin D/genetics; Chromogenic Compounds/chemistry; Computer Simulation; Escherichia coli/genetics; Fibroblasts/enzymology; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Oligopeptides/chemistry; Placenta/enzymology; Protease Inhibitors/metabolism; Recombinant Proteins/metabolism; Structure-Activity Relationship; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Chromogenic Compounds / Cathepsin D Type of study: Prognostic_studies Limits: Humans Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 1993 Document type: Article Country of publication: United States

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