Your browser doesn't support javascript.
loading
HLA antigen familial study in complete Behçet's syndrome affecting three sisters.
Villanueva, J L; Gonzalez-Dominguez, J; Gonzalez-Fernandez, R; Prada, J L; Peña, J; Solana, R.
Affiliation
  • Villanueva JL; Service of Internal Medicine, Hospital Regional Universitario Reina Sofia, Cordoba, Spain.
Ann Rheum Dis ; 52(2): 155-7, 1993 Feb.
Article in En | MEDLINE | ID: mdl-8447696
Behçet's disease is a multisystemic disease affecting most organs. Although a tendency towards an association with a certain genetic type and with HLA-B51 is suspected, the incidence of several siblings with Behçet's disease in a single family is rare. A family, in which three sisters were affected with Behçet's disease, uveitis being the most severe manifestation, was studied. In this family all siblings were B51 positive. Only the female siblings, however, with a positive identical HLA phenotype: A2, A11, B51, B44, Cw6, Cw5, DR4, DRw13, DRw53, DRw52, DQw7, DQw6, developed the disease symptoms, whereas none of the male siblings was affected.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Behcet Syndrome / HLA Antigens Limits: Adult / Female / Humans / Male Language: En Journal: Ann Rheum Dis Year: 1993 Document type: Article Affiliation country: Spain Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Behcet Syndrome / HLA Antigens Limits: Adult / Female / Humans / Male Language: En Journal: Ann Rheum Dis Year: 1993 Document type: Article Affiliation country: Spain Country of publication: United kingdom