Cerebrocerebellar relationships in normal subjects and patients with dementia of the Alzheimer type: a SPECT study.
Ann Nucl Med
; 7(1): 45-50, 1993 Feb.
Article
in En
| MEDLINE
| ID: mdl-8461238
ABSTRACT
The relationships between blood flow in the cerebrum and the cerebellum was investigated in 21 normal subjects and 21 patients with dementia of the Alzheimer type (DAT). In normal subjects, only asymmetry in the frontal cortical blood flow was significantly correlated with asymmetry in the contralateral cerebellar blood flow. However, a significant correlation between asymmetry in the cerebral cortical blood flow in many areas and the blood flow in the contralateral cerebellum in DAT patients was observed. These results suggest the existence of a functional relationship between the cerebrum and the cerebellum in both normal and DAT groups, mediated by neuronal mechanisms through crossed fiber pathways. However, there are regional differences in the cerebrocerebellar relationship in normal resting and pathological states.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebellum
/
Cerebral Cortex
/
Cerebrovascular Circulation
/
Alzheimer Disease
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ann Nucl Med
Journal subject:
MEDICINA NUCLEAR
Year:
1993
Document type:
Article
Affiliation country:
Japan