A cationic region of the platelet-derived growth factor (PDGF) A-chain (Arg159-Lys160-Lys161) is required for receptor binding and mitogenic activity of the PDGF-AA homodimer.

Fenstermaker, R A; Poptic, E; Bonfield, T L; Knauss, T C; Corsillo, L; Piskurich, J F; Kaetzel, C S; Jentoft, J E; Gelfand, C; DiCorleto, P E

Fenstermaker, R A; Poptic, E; Bonfield, T L; Knauss, T C; Corsillo, L; Piskurich, J F; Kaetzel, C S; Jentoft, J E; Gelfand, C; DiCorleto, P E.

Affiliation

Fenstermaker RA; Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106.

J Biol Chem ; 268(14): 10482-9, 1993 May 15.

Article in En | MEDLINE | ID: mdl-8486701

Subject(s)

Platelet-Derived Growth Factor/metabolism; Platelet-Derived Growth Factor/pharmacology; Receptors, Platelet-Derived Growth Factor/metabolism; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Circular Dichroism; Cricetinae; Enhancer Elements, Genetic; Genetic Vectors; Kinetics; Macromolecular Substances; Methotrexate/pharmacology; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Platelet-Derived Growth Factor/genetics; Polymerase Chain Reaction/methods; Promoter Regions, Genetic; RNA, Messenger/genetics; RNA, Messenger/metabolism; Radioligand Assay; Recombinant Proteins/isolation & purification; Recombinant Proteins/metabolism; Recombinant Proteins/pharmacology; Restriction Mapping; Tetrahydrofolate Dehydrogenase/genetics; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Platelet-Derived Growth Factor / Receptors, Platelet-Derived Growth Factor Limits: Animals Language: En Journal: J Biol Chem Year: 1993 Document type: Article Country of publication: United States

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