Construction of an HIV-1 peptide vaccine containing a multideterminant helper peptide linked to a V3 loop peptide 18 inducing strong neutralizing antibody responses in mice of multiple MHC haplotypes after two immunizations.

Ahlers, J D; Pendleton, C D; Dunlop, N; Minassian, A; Nara, P L; Berzofsky, J A

Ahlers, J D; Pendleton, C D; Dunlop, N; Minassian, A; Nara, P L; Berzofsky, J A.

Affiliation

Ahlers JD; Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institute of Health, Bethesda, MD 20892.

J Immunol ; 150(12): 5647-65, 1993 Jun 15.

Article in En | MEDLINE | ID: mdl-8515081

Subject(s)

AIDS Vaccines/immunology; Gene Products, env/immunology; HIV Antibodies/biosynthesis; HIV-1/immunology; Major Histocompatibility Complex; Peptide Fragments/immunology; Protein Precursors/immunology; Amino Acid Sequence; Animals; Antibody Affinity; Binding, Competitive; HIV Envelope Protein gp160; Haplotypes; Immunization; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neutralization Tests; Vaccines, Synthetic/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Protein Precursors / HIV Antibodies / Gene Products, env / HIV-1 / AIDS Vaccines / Major Histocompatibility Complex Limits: Animals Language: En Journal: J Immunol Year: 1993 Document type: Article Country of publication: United States

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