Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

Fairbanks, L D; Bofill, M; Ruckemann, K; Simmonds, H A

Fairbanks, L D; Bofill, M; Ruckemann, K; Simmonds, H A.

Affiliation

Fairbanks LD; Purine Research Laboratory, United Medical School, Guy's Hospital, London, United Kingdom.

J Biol Chem ; 270(50): 29682-9, 1995 Dec 15.

Article in En | MEDLINE | ID: mdl-8530356

Subject(s)

DNA/biosynthesis; Lymphocyte Activation; Ribonucleotides/blood; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Azaserine/pharmacology; Carbon Radioisotopes; Cells, Cultured; Chromatography, High Pressure Liquid/methods; Humans; Kinetics; Models, Biological; Phytohemagglutinins; Purine Nucleosides/blood; Purine Nucleosides/isolation & purification; Purine Nucleotides/blood; Purine Nucleotides/isolation & purification; Pyrimidine Nucleosides/blood; Pyrimidine Nucleosides/isolation & purification; Pyrimidine Nucleotides/blood; Pyrimidine Nucleotides/isolation & purification; Radioisotope Dilution Technique; Reference Values; Ribavirin/pharmacology; Sensitivity and Specificity; T-Lymphocytes/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Ribonucleotides / DNA / Lymphocyte Activation / T-Lymphocytes Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 1995 Document type: Article Affiliation country: United kingdom Country of publication: United States

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