Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
Science
; 271(5247): 363-6, 1996 Jan 19.
Article
in En
| MEDLINE
| ID: mdl-8553074
ABSTRACT
beta-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by uncoupling the signal transduction process. Resensitization of GPCR responsiveness involves agonist-mediated receptor sequestration. Overexpression of beta-arrestins in human embryonic kidney cells rescued the sequestration of beta 2-adrenergic receptor (beta 2AR) mutants defective in their ability to sequester, an effect enhanced by simultaneous overexpression of beta-adrenergic receptor kinase 1. Wild-type beta 2AR sequestration was inhibited by the overexpression of two beta-arrestin mutants. These findings suggest that beta-arrestins play an integral role in GPCR internalization and thus serve a dual role in the regulation of GPCR function.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Adrenergic, beta-2
/
Cyclic AMP-Dependent Protein Kinases
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Adrenergic beta-Agonists
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GTP-Binding Proteins
/
Arrestins
/
Eye Proteins
/
Antigens
Limits:
Humans
Language:
En
Journal:
Science
Year:
1996
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA