Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity.

Ells, G W; Chisholm, K A; Simmons, V A; Horrobin, D F

Ells, G W; Chisholm, K A; Simmons, V A; Horrobin, D F.

Affiliation

Ells GW; Efamol Research Institute, Kentville, Nova Scotia, Canada.

Cancer Lett ; 98(2): 207-11, 1996 Jan 02.

Article in En | MEDLINE | ID: mdl-8556710

Subject(s)

Antioxidants/pharmacology; Vitamin E/pharmacology; gamma-Linolenic Acid/antagonists & inhibitors; gamma-Linolenic Acid/toxicity; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Cell Death/drug effects; Fluorescence; Humans; Time Factors; Tumor Cells, Cultured/drug effects; Vitamin E/pharmacokinetics; gamma-Linolenic Acid/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Vitamin E / Gamma-Linolenic Acid / Antioxidants Limits: Humans Language: En Journal: Cancer Lett Year: 1996 Document type: Article Affiliation country: Canada Country of publication: Ireland

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