[Fluconazole level in aqueous humor after oral drug administration in humans]. / Fluconazolspiegel im Kammerwasser nach oraler Wirkstoffgabe beim Menschen.
Ophthalmologe
; 92(6): 829-32, 1995 Dec.
Article
in De
| MEDLINE
| ID: mdl-8563432
ABSTRACT
For 2 years fluconazole, a triazole antimycotic, has been available for treatment of systemic mycosis. Compared to amphotericin B fewer severe side effects have been reported. So far, no data have been published as to its penetration into the human eye. In the present study, 20 cataract patients were given 200 mg fluconazole (0.5 to 8 h preoperatively. During the cataract operation 0.1 ml of the aqueous was removed as well as 10 ml serum. With the help of high-pressure liquid chromatography (HPLC), the concentration of fluconazole in each of the samples was determine. If the aqueous humor was removed at least 2h after fluconazole application, concentrations between 2.7 and 5.4 micrograms/ml were reached (mean 3.7 +/- 2.17) In these cases the concentration in the aqueous humor was 80% of the concentration found in the serum at the same time. If the sample of the aqueous humor was collected only 1 h after application, 40% of the concentration in the serum was found in the aqueous humor. These data prove that fluconazole shows an extremely good penetration through the blood-aqueous barrier. After a single dose of 200 mg, a concentration is reached in the eye that surmounts the minimal inhibiting concentration found for Candida species sensitive to fluconazole. Therefore, fluconazole seems to be a good alternative to amphotericin B for the treatment of infections caused by such fungi.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aqueous Humor
/
Fluconazole
/
Antibiotic Prophylaxis
/
Antifungal Agents
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
De
Journal:
Ophthalmologe
Journal subject:
OFTALMOLOGIA
Year:
1995
Document type:
Article