In vivo metabolism of benzo(a)pyrene in a lower vertebrate, the newt Pleurodeles walt.
Ecotoxicol Environ Saf
; 32(1): 51-7, 1995 Oct.
Article
in En
| MEDLINE
| ID: mdl-8565877
The capacity of the newt to metabolize benzo(a)pyrene in vivo was investigated qualitatively and quantitatively: metabolism was found to be rapid. Treatment of bile with beta-glucuronidase and aryl-sulfatase released high proportions of diols and quinones. 3-Methylcholanthrene treatment shortened the elimination half-life of benzo(a)pyrene which was about three times shorter than the half-life found for non-3-methylcholanthrene-pretreated animals. Thus, a greater proportion of benzo(a)pyrene was converted into water-soluble products.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pleurodeles
/
Benzo(a)pyrene
/
Environmental Pollutants
Limits:
Animals
Language:
En
Journal:
Ecotoxicol Environ Saf
Year:
1995
Document type:
Article
Affiliation country:
France
Country of publication:
Netherlands