Manipulation of costimulatory signals to enhance antitumor T-cell responses.
Curr Opin Immunol
; 7(5): 682-6, 1995 Oct.
Article
in En
| MEDLINE
| ID: mdl-8573312
ABSTRACT
One of the major goals of tumor immunotherapy is the induction of tumor-specific T-cell responses that will be effective in eradicating disseminated tumors. Emerging information on the role of costimulatory molecules in T-cell activation offers several new strategies for enhancing antitumor responses, including the induction of expression of costimulatory molecules on tumor cells, enhancement of the presentation of transferred tumor antigen by host antigen-presenting cells, and ex vivo antigen priming of autologous antigen-presenting cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
T-Lymphocytes
/
Immunotherapy
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
1995
Document type:
Article
Affiliation country:
United States