Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride in rats.
Pharmacol Toxicol
; 77(4): 293-8, 1995 Oct.
Article
in En
| MEDLINE
| ID: mdl-8577643
ABSTRACT
Intravenous injection of gadolinium chloride (GdCl3) at a dose of 10 mg/kg caused an increase in proliferating cell nuclear antigen labeling index and the grade of pyronin positivity (RNA level) in rat liver. In CCl4-exposed rats, pretreatment with GdCl3 also showed a preventive effect of the liver injury both biochemically and histologically. Moreover, the proliferative action preceded the attenuative effect of the liver injury. Results suggest that GdCl3 induces hepatocyte proliferation, and this action of GdCl3 may modify the development of CCl4-induced liver injury.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbon Tetrachloride
/
Gadolinium
/
Liver
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Pharmacol Toxicol
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
1995
Document type:
Article
Affiliation country:
Japan