Distribution of HLA-DPB1, -DQB1 -DQA1 alleles among Sardinian celiac patients.
Dis Markers
; 12(3): 199-204, 1995 Aug.
Article
in En
| MEDLINE
| ID: mdl-8590546
ABSTRACT
The Sardinian population in many aspects differs from other Caucasoid populations, particularly for its degree of homogeneity. For this reason we have studied 50 adult Sardinian patients with celiac disease (CD) and 50 control healthy Sardinian individuals by RFLP analysis and by extensive oligotyping for 17 HLA-DPB1, 8-DQB1 and 9-DQA1 alleles, and established their -DPB1 alleles and -DQB1 -DQA1 genotypes. The heterodimer HLA-DQB1*0201/-DQA1*0501, present in 96% of our patients, is strongly associated with CD susceptibility, confirming published reports. On the other hand we found in 11 of 50 probands (22%) the presence of the allele -DQB1*0502/DQA1*0102. This genotype is extremely rare in other Caucasian populations and appears to confer limited protection in CD Sardinian patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HLA-DP Antigens
/
HLA-DQ Antigens
/
Celiac Disease
/
Alleles
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Dis Markers
Journal subject:
BIOQUIMICA
Year:
1995
Document type:
Article
Affiliation country:
Italy