Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3'-methyl-4-dimethylamino-azobenzene.
Biol Pharm Bull
; 18(10): 1443-5, 1995 Oct.
Article
in En
| MEDLINE
| ID: mdl-8593453
ABSTRACT
The effects of gomisin A, a lignan component of Schizandra fruits, on the promotion stage of hepatocarcinogenesis initiated by 3'-methyl-4-dimethylamino-azobenzene (3'-MeDAB) in male Donryu rats were investigated. When different types of tumor promotors, phenobarbital (PB) and deoxycholic acid (DCA), were administered for 5 weeks after initiation by 3'-MeDAB, preneoplastic alterations in the liver, determined by glutathione S-transferase placental form (GST-P), were markedly increased. Gomisin A significantly inhibited the increase in number and size of GST-P positive foci, regardless of the promotor. This lignan inhibited the increase in serum bile acid concentration by administration of DCA, but hardly influenced the serum bile acids in the PB-combined group. These results suggest that the inhibitory effect of gomisin A on the promotive action of DCA is based on improving bile acid metabolism, but regarding the action of PB, the effect could not be elucidated from the metabolism of bile acids.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bile Acids and Salts
/
Carcinogens
/
Anticarcinogenic Agents
/
Lignans
/
Cyclooctanes
/
Dioxoles
/
Liver Neoplasms, Experimental
/
Methyldimethylaminoazobenzene
Limits:
Animals
Language:
En
Journal:
Biol Pharm Bull
Journal subject:
BIOQUIMICA
/
FARMACOLOGIA
Year:
1995
Document type:
Article
Affiliation country:
Japan