Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli.
Antimicrob Agents Chemother
; 39(10): 2359-63, 1995 Oct.
Article
in En
| MEDLINE
| ID: mdl-8619599
The DNA fragment (3.3 kb) containing the erythromycin resistance determinant was cloned from Escherichia coli Tf481A and sequenced. Deletion and complementation analyses indicated that the expression of high-level resistance to erythromycin requires two genes, mphA and mrx, which encode macrolide 2'-phosphotransferase I and an unidentified hydrophobic protein, respectively.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphotransferases
/
Drug Resistance, Microbial
/
Erythromycin
/
Phosphotransferases (Alcohol Group Acceptor)
/
Escherichia coli
/
Anti-Bacterial Agents
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
1995
Document type:
Article
Affiliation country:
Japan
Country of publication:
United States