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Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli.
Noguchi, N; Emura, A; Matsuyama, H; O'Hara, K; Sasatsu, M; Kono, M.
Affiliation
  • Noguchi N; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Antimicrob Agents Chemother ; 39(10): 2359-63, 1995 Oct.
Article in En | MEDLINE | ID: mdl-8619599
The DNA fragment (3.3 kb) containing the erythromycin resistance determinant was cloned from Escherichia coli Tf481A and sequenced. Deletion and complementation analyses indicated that the expression of high-level resistance to erythromycin requires two genes, mphA and mrx, which encode macrolide 2'-phosphotransferase I and an unidentified hydrophobic protein, respectively.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphotransferases / Drug Resistance, Microbial / Erythromycin / Phosphotransferases (Alcohol Group Acceptor) / Escherichia coli / Anti-Bacterial Agents Language: En Journal: Antimicrob Agents Chemother Year: 1995 Document type: Article Affiliation country: Japan Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphotransferases / Drug Resistance, Microbial / Erythromycin / Phosphotransferases (Alcohol Group Acceptor) / Escherichia coli / Anti-Bacterial Agents Language: En Journal: Antimicrob Agents Chemother Year: 1995 Document type: Article Affiliation country: Japan Country of publication: United States