Structure-based design of novel, urea-containing FKBP12 inhibitors.

Dragovich, P S; Barker, J E; French, J; Imbacuan, M; Kalish, V J; Kissinger, C R; Knighton, D R; Lewis, C T; Moomaw, E W; Parge, H E; Pelletier, L A; Prins, T J; Showalter, R E; Tatlock, J H; Tucker, K D; Villafranca, J E

Dragovich, P S; Barker, J E; French, J; Imbacuan, M; Kalish, V J; Kissinger, C R; Knighton, D R; Lewis, C T; Moomaw, E W; Parge, H E; Pelletier, L A; Prins, T J; Showalter, R E; Tatlock, J H; Tucker, K D; Villafranca, J E.

Affiliation

Dragovich PS; Agouron Pharmaceuticals, Inc., San Diego, California 92121, USA.

J Med Chem ; 39(9): 1872-84, 1996 Apr 26.

Article in En | MEDLINE | ID: mdl-8627611

Subject(s)

Carrier Proteins/antagonists & inhibitors; DNA-Binding Proteins/antagonists & inhibitors; Drug Design; Heat-Shock Proteins/antagonists & inhibitors; Urea/analysis; Amino Acid Isomerases/antagonists & inhibitors; Amino Acid Sequence; Carrier Proteins/chemistry; Crystallography, X-Ray; DNA-Binding Proteins/chemistry; Heat-Shock Proteins/chemistry; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptidylprolyl Isomerase; Structure-Activity Relationship; Tacrolimus/chemistry; Tacrolimus Binding Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Urea / Drug Design / Carrier Proteins / DNA-Binding Proteins / Heat-Shock Proteins Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Document type: Article Affiliation country: United States Country of publication: United States

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