Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.

Nakayama, K; Ishida, N; Shirane, M; Inomata, A; Inoue, T; Shishido, N; Horii, I; Loh, D Y; Nakayama, K

Nakayama, K; Ishida, N; Shirane, M; Inomata, A; Inoue, T; Shishido, N; Horii, I; Loh, D Y; Nakayama, K.

Affiliation

Nakayama K; Department of Biology, Nippon Roche Research Center, Kamakura, Kanagawa, Japan.

Cell ; 85(5): 707-20, 1996 May 31.

Article in En | MEDLINE | ID: mdl-8646779

Subject(s)

Body Constitution/genetics; Cell Cycle Proteins; Microtubule-Associated Proteins/genetics; Pituitary Neoplasms/genetics; Retinal Dysplasia/genetics; Tumor Suppressor Proteins; Animals; Base Sequence; Cell Cycle/genetics; Cell Division/drug effects; Cell Division/genetics; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases/antagonists & inhibitors; DNA Primers/genetics; DNA, Complementary/genetics; Enzyme Inhibitors/metabolism; Female; Gene Expression; Gene Targeting; Genes, Tumor Suppressor; Heterozygote; Hyperplasia; Infertility, Female/genetics; Male; Mice; Mice, Knockout; Microtubule-Associated Proteins/physiology; Molecular Sequence Data; Phenotype; Polyenes/pharmacology; Sirolimus; Tissue Distribution; Transforming Growth Factor alpha/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Pituitary Neoplasms / Body Constitution / Retinal Dysplasia / Cell Cycle Proteins / Tumor Suppressor Proteins / Microtubule-Associated Proteins Limits: Animals Language: En Journal: Cell Year: 1996 Document type: Article Affiliation country: Japan Country of publication: United States

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