Cocarcinogenic interaction between D,L-tryptophan and 4-aminobiphenyl or 2-naphthylamine in dogs.
J Natl Cancer Inst
; 58(6): 1831-4, 1977 Jun.
Article
in En
| MEDLINE
| ID: mdl-864760
ABSTRACT
Administration of a dietary supplement of 6 g D,L tryptophan/day for 4 1/2 years following the administration of a single dose of 50 mg 4-aminobiphenyl/kg produced a bladder tumor in 1 of 4 beagle dogs. No tumors were observed in 6 dogs given the same dose of 4-aminobiphenyl without supplemental tryptophan. In a second experiment, administration of a supplement of 6 g D,L-tryptophan/day for 3 years following the administration of 5 mg 2-naphthylamine/kg/day for 30 days produced bladder tumors in 2 of 4 dogs. No tumors or other bladder pathology was produced by treatment of 4 dogs with this dose of 2-naphthylamine alone. Dogs given D,L-tryptophan alone developed no bladder tumors, but in most dogs receiving tryptophan the "tryptophan effect", i.e., a darkly stained mucosa with white areas of focal hyperplasia, was observed. Both experiments suggest a role of D,L-tryptophan as a cocarcinogen or promotor in the induction of bladder cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tryptophan
/
Urinary Bladder Neoplasms
/
Carcinogens
/
Aminobiphenyl Compounds
/
Naphthalenes
/
2-Naphthylamine
Limits:
Animals
Language:
En
Journal:
J Natl Cancer Inst
Year:
1977
Document type:
Article