Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite E-3174.

Goldberg, M R; Lo, M W; Deutsch, P J; Wilson, S E; McWilliams, E J; McCrea, J B

Goldberg, M R; Lo, M W; Deutsch, P J; Wilson, S E; McWilliams, E J; McCrea, J B.

Affiliation

Goldberg MR; Division of Clinical Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.

Clin Pharmacol Ther ; 59(3): 268-74, 1996 Mar.

Article in En | MEDLINE | ID: mdl-8653989

Subject(s)

Antihypertensive Agents/pharmacokinetics; Biphenyl Compounds/pharmacokinetics; Imidazoles/blood; Imidazoles/pharmacokinetics; Phenobarbital/pharmacology; Tetrazoles/blood; Tetrazoles/pharmacokinetics; Adult; Anticonvulsants/pharmacology; Antihypertensive Agents/blood; Biphenyl Compounds/blood; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/biosynthesis; Enzyme Induction/drug effects; Humans; Hydrocortisone/analogs & derivatives; Hydrocortisone/urine; Hypnotics and Sedatives/pharmacology; Losartan; Male; Mixed Function Oxygenases/biosynthesis; Reference Values; Single-Blind Method

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Collection: 01-internacional Database: MEDLINE Main subject: Phenobarbital / Tetrazoles / Biphenyl Compounds / Imidazoles / Antihypertensive Agents Type of study: Clinical_trials Limits: Adult / Humans / Male Language: En Journal: Clin Pharmacol Ther Year: 1996 Document type: Article Affiliation country: United States Country of publication: United States

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