Induction of phenazine biosynthesis in cultures of Pseudomonas aeruginosa by L-N-(3-oxohexanoyl)homoserine lactone.
FEMS Microbiol Lett
; 140(1): 15-22, 1996 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-8666196
ABSTRACT
A range of Pseudomonas spp. and other Gram-negative bacteria were screened for induction of antimicrobial activity in response to the autoregulatory factor L-N-(3-oxohexanoyl)homoserine lactone. In one of these, P. aeruginosa ATCC 10145, the production of phenazine metabolites was shown to be inducible in a dose-dependent manner. The production of phenazine-1-carboxamide increased over 50-fold compared to control cultures when supplemented with 200 micrograms/ml of the autoregulator. In addition, the production of an unidentified polar antibacterial substance by this strain increased with autoregulator concentration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenazines
/
Pheromones
/
Pseudomonas aeruginosa
/
4-Butyrolactone
Language:
En
Journal:
FEMS Microbiol Lett
Year:
1996
Document type:
Article
Affiliation country:
United kingdom