Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.

Nugiel, D A; Jacobs, K; Kaltenbach, R F; Worley, T; Patel, M; Meyer, D T; Jadhav, P K; De Lucca, G V; Smyser, T E; Klabe, R M; Bacheler, L T; Rayner, M M; Seitz, S P

Nugiel, D A; Jacobs, K; Kaltenbach, R F; Worley, T; Patel, M; Meyer, D T; Jadhav, P K; De Lucca, G V; Smyser, T E; Klabe, R M; Bacheler, L T; Rayner, M M; Seitz, S P.

Affiliation

Nugiel DA; Dupont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500, USA.

J Med Chem ; 39(11): 2156-69, 1996 May 24.

Article in En | MEDLINE | ID: mdl-8667359

Subject(s)

Azepines/chemical synthesis; HIV Protease Inhibitors/chemistry; HIV Protease/chemistry; HIV Protease/metabolism; Urea/analogs & derivatives; Urea/chemical synthesis; Azepines/chemistry; Azepines/pharmacology; Binding Sites; Cell Line; Cell Survival/drug effects; Crystallography, X-Ray; HIV Protease Inhibitors/chemical synthesis; HIV Protease Inhibitors/pharmacology; HIV-1/enzymology; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Structure; Protein Binding; Structure-Activity Relationship; Urea/chemistry; Urea/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Urea / HIV Protease / HIV Protease Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Document type: Article Affiliation country: United States

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