p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.

Fotedar, R; Fitzgerald, P; Rousselle, T; Cannella, D; Dorée, M; Messier, H; Fotedar, A

Fotedar, R; Fitzgerald, P; Rousselle, T; Cannella, D; Dorée, M; Messier, H; Fotedar, A.

Affiliation

Fotedar R; Institut de Biologie Structurale J-P Ebel, Grenoble, France.

Oncogene ; 12(10): 2155-64, 1996 May 16.

Article in En | MEDLINE | ID: mdl-8668341

Subject(s)

CDC2-CDC28 Kinases; Cyclin-Dependent Kinases/antagonists & inhibitors; Cyclin-Dependent Kinases/metabolism; Cyclins/metabolism; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/metabolism; Amino Acid Sequence; Animals; Baculoviridae/genetics; Baculoviridae/metabolism; Binding Sites; Burkitt Lymphoma/metabolism; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclins/genetics; Humans; Molecular Sequence Data; Mutation; Peptide Mapping; Spodoptera/virology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Cyclins / Cyclin-Dependent Kinases / CDC2-CDC28 Kinases Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 1996 Document type: Article Affiliation country: France

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