Comparative conformational analysis of CCK-B agonist Boc-Trp-Phg-Asp-(1-Nal)-NH2 and CCK1-B antagonist Boc-Trp-Phg-Asp-(1-Nal)-N(Me)2 using 1HNMR spectroscopy and restrained molecular dynamics.

Goudreau, N; Weng, J H; Roques, B P

Goudreau, N; Weng, J H; Roques, B P.

Affiliation

Goudreau N; Départment de Pharmacochimie Moléculaire et Structurale, U266 INSERM-URA D1500 CNRS, U.F.R. des Sciences Pharmaceutiques et Biologiques, Paris, France.

Arch Pharm (Weinheim) ; 329(4): 197-204, 1996 Apr.

Article in En | MEDLINE | ID: mdl-8669984

Subject(s)

Oligopeptides/chemistry; Oligopeptides/pharmacology; Receptors, Cholecystokinin/agonists; Receptors, Cholecystokinin/antagonists & inhibitors; Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Ligands; Magnetic Resonance Spectroscopy/methods; Molecular Sequence Data; Protein Conformation; Receptor, Cholecystokinin B; Thermodynamics

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Receptors, Cholecystokinin Type of study: Prognostic_studies Language: En Journal: Arch Pharm (Weinheim) Year: 1996 Document type: Article Affiliation country: France

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