[Medical treatment of aortic abdominal aneurysms. Outstanding questions]. / Traitement médical des anévrysmes de l'aorte abdominale. Questions en suspens.
Presse Med
; 25(14): 683-5, 1996 Apr 20.
Article
in Fr
| MEDLINE
| ID: mdl-8685126
ABSTRACT
The low mortality of programmed surgical treatment of aortic abdominal aneurysms (2-4%) contrasts with a high mortality of surgical treatment in case of rupture (70-90%). These data underline the benefit of a "prophylactic" surgical treatment of aortic abdominal aneurysms, even those of small size or in older patients. Recently, experimental models and results of a few clinical studies suggest that medical treatment with beta-adrenergic blocking agents may reduce the expansion rate of aortic abdominal aneurysms and thus lower the risk of rupture. Several questions remains open. Should beta-blocking agents be reserved for aneurysms more than 5 cm in diameter in patients with a contraindication for surgery, or on the contrary proposed for aneurysms less than 4 cm in diameter in patients still free of contraindications? What is the mode and delay of action for beta-blockers, their effect on modulating blood pressure and their contribution to the use of endoluminal prostheses? Controlled prospective trials enrolling a large number of patients are required to answer these questions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aortic Aneurysm, Abdominal
/
Adrenergic beta-Antagonists
Limits:
Humans
Language:
Fr
Journal:
Presse Med
Year:
1996
Document type:
Article