Intranasal monoclonal IgA antibody to respiratory syncytial virus protects rhesus monkeys against upper and lower respiratory tract infection.

Weltzin, R; Traina-Dorge, V; Soike, K; Zhang, J Y; Mack, P; Soman, G; Drabik, G; Monath, T P

Weltzin, R; Traina-Dorge, V; Soike, K; Zhang, J Y; Mack, P; Soman, G; Drabik, G; Monath, T P.

Affiliation

Weltzin R; OraVax, Inc., Cambridge, Massachusetts 02139, USA.

J Infect Dis ; 174(2): 256-61, 1996 Aug.

Article in En | MEDLINE | ID: mdl-8699052

Subject(s)

Antibodies, Monoclonal/therapeutic use; Antibodies, Viral/therapeutic use; HN Protein; Immunoglobulin A, Secretory/therapeutic use; Respiratory Syncytial Virus Infections/prevention & control; Respiratory Tract Infections/prevention & control; Viral Proteins/immunology; Administration, Intranasal; Animals; Bronchoalveolar Lavage Fluid/virology; Disease Models, Animal; Dose-Response Relationship, Drug; Macaca mulatta; Mice; Nasal Mucosa/immunology; Pharynx/virology; Respiratory Syncytial Viruses/immunology; Respiratory Syncytial Viruses/isolation & purification; Time Factors; Viral Envelope Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Tract Infections / Viral Proteins / Immunoglobulin A, Secretory / HN Protein / Respiratory Syncytial Virus Infections / Antibodies, Monoclonal / Antibodies, Viral Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Infect Dis Year: 1996 Document type: Article Affiliation country: United States

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