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Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons.
Mahalingam, R; Wellish, M; Cohrs, R; Debrus, S; Piette, J; Rentier, B; Gilden, D H.
Affiliation
  • Mahalingam R; Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.
Proc Natl Acad Sci U S A ; 93(5): 2122-4, 1996 Mar 05.
Article in En | MEDLINE | ID: mdl-8700895
ABSTRACT
The ganglionic cell type in which varicella-zoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein. VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trans-Activators / Viral Envelope Proteins / Trigeminal Ganglion / Virus Latency / Immediate-Early Proteins / Herpesvirus 3, Human / Ganglia, Sympathetic Type of study: Prognostic_studies Limits: Adult / Humans / Infant Language: En Journal: Proc Natl Acad Sci U S A Year: 1996 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trans-Activators / Viral Envelope Proteins / Trigeminal Ganglion / Virus Latency / Immediate-Early Proteins / Herpesvirus 3, Human / Ganglia, Sympathetic Type of study: Prognostic_studies Limits: Adult / Humans / Infant Language: En Journal: Proc Natl Acad Sci U S A Year: 1996 Document type: Article Affiliation country: United States