Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.

van Rhee, A M; Jiang, J L; Melman, N; Olah, M E; Stiles, G L; Jacobson, K A

van Rhee, A M; Jiang, J L; Melman, N; Olah, M E; Stiles, G L; Jacobson, K A.

Affiliation

van Rhee AM; Molecular Recognition Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA.

J Med Chem ; 39(15): 2980-9, 1996 Jul 19.

Article in En | MEDLINE | ID: mdl-8709132

Subject(s)

Calcium Channel Blockers/chemical synthesis; Dihydropyridines/chemistry; Dihydropyridines/chemical synthesis; Purinergic P1 Receptor Antagonists; Pyridines/chemical synthesis; Adenylyl Cyclase Inhibitors; Animals; CHO Cells; Calcium Channel Blockers/metabolism; Calcium Channels/metabolism; Cell Membrane/metabolism; Cerebral Cortex/metabolism; Cricetinae; Dihydropyridines/metabolism; Dihydropyridines/pharmacology; Enzyme Inhibitors/pharmacology; Guinea Pigs; Humans; Isradipine/metabolism; Molecular Structure; Pyridines/metabolism; Rats; Receptors, Purinergic P1/metabolism; Recombinant Proteins/metabolism; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Dihydropyridines / Calcium Channel Blockers / Purinergic P1 Receptor Antagonists Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Document type: Article Affiliation country: United States

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