A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease.
Neurology
; 47(1): 256-9, 1996 Jul.
Article
in En
| MEDLINE
| ID: mdl-8710089
ABSTRACT
We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apolipoproteins E
/
Alzheimer Disease
/
Genotype
/
Mental Disorders
Type of study:
Diagnostic_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neurology
Year:
1996
Document type:
Article
Affiliation country:
United States