The specificity of interactions between the cortex and the thalamus.
Ciba Found Symp
; 193: 173-91; discussion 192-9, 1995.
Article
in En
| MEDLINE
| ID: mdl-8727492
ABSTRACT
The functioning of the adult mammalian cerebral cortex depends critically upon precise interconnections between specific thalamic nuclei and distinct cortical regions. Therefore, one central issue in understanding cortical development is determining the cellular and molecular strategies underlying the specification of thalamocortical projections. We address the role of axon-axon interactions and membrane-bound guidance molecules in the establishment of the development of layer-specific patterns of afferent and efferent cortical connections does not depend upon neuronal activity. We present evidence that activity conveyed by thalamic afferents is required for the elaboration of the columnar specificity of cortical circuits.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thalamus
/
Cerebral Cortex
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Ciba Found Symp
Year:
1995
Document type:
Article
Affiliation country:
France
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS